Web10 Dec 2024 · PINK1 overexpression reversed the abnormal changes in mitochondrial dynamics, defective mitophagy, and decreased ATP levels in the hippocampus. Moreover, … Web12 Jun 2024 · Parkin overexpression also confers protection in various models of cellular senescence and neurological disorders closely associated with ageing, such as Alzheimer's and Parkinson's diseases. Recently, Parkin overexpression has also been shown to suppress tumour growth. In this review, we discuss newly emerging biological roles of …
DUSP1 overexpression attenuates renal tubular ... - ScienceDirect
Web7 Jun 2024 · PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury 2024 Jun 7;27 (6):184. Authors Pengpeng Duan 1 , Jin Tan 1 , Yuyang Miao 1 , Qiang Zhang 1 Affiliation 1 Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, 300052 Tianjin, China. WebMutations of parkin are linked to early onset Parkinson disease. Here we show that stable transfection of parkin in the human dopaminergic neuroblastoma cell line SH-SY5Y markedly reduced the activities of both monoamine oxidase (MAO) A and B. The amount of 3,4-dihydroxyphenylacetic acid, which is produced during dopamine oxidation by MAO, … free teamviewer for personal use
PubMed
Web12 Nov 2024 · Overexpressing Parkin promotes proteostasis and function of aged muscles both in fruit flies and mice, and recent studies also indicated that mitochondrial ubiquitination are accumulated in aged muscles. However, the underlying mechanisms for pink1 and parkin mediated mitophagy on longevity is not fully understood. Web17 Jan 2024 · Interestingly, parkin overexpression inhibited Aβ-induced mitochondrial dysfunction. Besides, parkin overexpression increased cytosolic and mitochondrial parkin levels as well as mitochondrial LC3-II levels in Aβ-treated cells. Web29 Jun 2010 · Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Mitochondrial genomes with deleterious mutations can … free teamviewer download for windows 10