High glucose macrophage
WebHigh glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1): inhibitory … Web7 de ago. de 2024 · High glucose levels appear to modify macrophage behaviour, affecting different aspects of diabetic and healthy BMDMs under the same LPS stimulus. Thus, hyperglycaemia leaves a glucose legacy ...
High glucose macrophage
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Web11 de jul. de 2024 · Long-term high glucose treatment reduced macrophage glycolytic capacity and glycolytic reserve without affecting mitochondrial ATP production … WebHDL-mediated cholesterol efflux from macrophages was significantly increased by 350% on using macrophages incubated with high glucose in the presence of insulin, compared to macrophages incubated only with glucose (18 ± 2% HDL-mediated cholesterol efflux from macrophages incubated with high glucose in the presence of insulin and 4 ± 2% in …
Web31 de mai. de 2024 · Amino acid and glucose metabolism are linked in reprogramming macrophage function. In fact, recent findings have shown that NO also impacts on mitochondrial cell bioenergetic pathways, probably thanks to its reactivity against iron-containing Fe-S clusters and heme moieties that are present in several proteins of the … Web1 de dez. de 2008 · Increased glucose is described to be involved in alterations of macrophages responses to lipopolysaccharide (LPS) in diabetic animal models, including interleukin-12 expression [5], upregulation of cyclooxygenase-II, leading to increased prostaglandin-E 2 [6] and TNF-α production [7].
WebThis study was, therefore, to investigate the mechanism by high glucose stimuli. Methods: In this study, Raw264.7 (murine macrophage cell line) cells were cultured and stimulated … Web27 de ago. de 2024 · Recently, the study indicated that HG-induced M1 macrophage exosomes activate macrophages and induce proinflammatory response, thereby promoting the progression of DKD [ 10 ]. It has still not been reported that whether HG-induced exosomes in M1 macrophages are related to podocyte injury in DKD.
WebThis study used a mouse model of sleeve gastrectomy to investigate the impacts of intravenous GLN administration on glucose tolerance and adipocyte inflammation short-term after surgery. C57BL6 male mice were divided into normal control (NC) and high-fat diet groups. The high-fat diet provided 60% of energy from fat for 10 weeks to induce …
WebNational Center for Biotechnology Information tsawwassen first nation treaty landsWebRAW264.7 were cultured in normal glucose (5.5 mM) or high glucose environment (25 mM) with or without NAC (8 mmol/L). LPS (100 ng/ml) and IL-4 (20 ng/ml) were used to … philly ferry scheduleWeb18 de jul. de 2024 · Nevertheless, diabetes-induced changes in macrophage secretory products remained largely unknown. We thus analyzed high-glucose (HG)-induced changes in secretome of human macrophages derived from U937 human monocytic cell line after phorbol 12-myristate 13-acetate (PMA) activation. tsawwassen flower deliveryWebWe evaluated the effect of high glucose conditions on the inflammatory profile and the autophagy pathway in Bone-Marrow Derived Macrophages ... Xu H, Chen M. Sustained … philly festivals 2021Web20 de jan. de 2024 · As shown in Figure 1A, macrophage-derived exosomal MALAT1 significantly increased from 12.5 mM to 50 mM of glucose concentration, and 25 mM high glucose had the maximal effect. Therefore, 25 mM high glucose was … tsawwassen flower shopWeb29 de out. de 2024 · The decrease in ETV5 expression resulted in macrophage ... EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice. Diabetes ... philly festivalWeb29 de jul. de 2007 · Macrophage inflammatory protein-3α (MIP-3α) is a CC chemokine that has been reported to attract memory T lymphocytes. Our previous microarray study showed significant increased level of MIP-3α in high glucose-induced transcriptional profile in renal proximal tubule cells. philly ferris wheel