Cisplatin hepatotoxicity
WebTo date, no published guidelines exist for managing a cisplatin overdose. The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, … WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver …
Cisplatin hepatotoxicity
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WebJan 14, 2024 · This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying … WebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. …
WebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … WebOne of greatest key mechanisms of Cis toxicity is the induction of oxidative stress. Under normal conditions, ROS are controlled by cells through harmonizing the production of ROS with their removal by scavenging system. Oxidative stress results in extreme damage of cellular proteins, lipids and DNA, leading to critical cellular injuries.
WebHepatotoxicity was induced in animals by an intraperitoneal injec-tion of acetaminophen (750 mg/kg body weight) in a freshly prepared physi-ological saline solution kept in warm boiling water bath and used after cooling at 370C, as a single dose on the first day. The rats were randomly divided into five groups of six animals each as given below. WebApr 1, 1993 · To report a case of possible cisplatin-associated hepatotoxicity. CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m 2 ) and …
WebPreventive Effect of Curcumin against Cisplatin-related Hepatotoxicity in Swiss Albino mice (Mus musculus L.) Jul 2024 - Jun 2024 …
WebMay 18, 2024 · Cisplatin is an anti-neoplastic agent for solid organ tumors has side effects on most organs including hepatotoxicity. 21, 22 In this study, we showed that CP can significantly induce hepatotoxicity in … iron wool experimentWebFeb 2, 2024 · There is substantial evidence that protective medications can alleviate drug-induced organ toxicity by modulating both Nrf2 and NF-κB signaling pathways. Thus, it has become increasingly important to explore the crosstalk mechanism between Nrf2 and NF-κB in drug-induced toxicity. iron work for windowsWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. iron wool coatWebDec 20, 2024 · Altered hepatic drug metabolism due to underlying liver disease can result in higher or more persistent drug levels, thereby causing increased systemic toxicity (particularly myelosuppression) or worsening of liver function because of … port talbot foodbankWebFeb 1, 2024 · Hesperidin plays an important role in the prevention of many diseases due to its anti-inflammatory, anti-oxidant, anti-ulcer, and anti-carcinogenic activities,2,3in addition to its anti-melanogenic and neuroprotective effects.4,5Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects.6-8The … iron woody fractional platesWebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … iron words wall decorWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). iron work meaning